Workshop 4: Cancer Development, Angiogenesis, Progression, and Invasion
(January 26-30, 2009)
Organizers: Kristin R. Swanson and Alexander Anderson
Cancer and tumor-induced angiogenesis has a natural place in the Special Year on Developmental Biology as cancer is often thought of as a result of a faulty development process. Experimental and clinical oncology forms a massive literature aimed at understanding and treating cancer. Despite the enormity of the data available, clinical oncologists and tumor biologists proceed without a comprehensive theoretical model to help guide the organization and understanding of such data. To quote a recent Nature article on the topic:
Heeding lessons from the physical sciences, one might expect to find oncology aggressively, almost desperately, pursuing quantitative methods to consolidate its vast body of data and integrate the rapidly accumulating new information. In fact, quite the contrary situation exists. Mathematical models are typically denounced as "too simplistic" for complex tumour-related phenomena (ignoring, of course, the fact that similar simplifying assumptions are required in most experimental designs). Articles in cancer journals rarely feature equations. Clinical oncologists and those who are interested in the mathematical modelling of cancer seldom share the same conference platforms. -- Nature 421, 321 (2003).
Naturally, successful modeling approaches to cancer requires scientists willing to communicate and interact extensively across disciplinary boundaries. This workshop aims to do exactly this by having truly interdisciplinary scientists as well as giving a shared platform for both experienced modellers and state-of-the art experimentalists and clinician-scientists discussing their work covering every level of tumor growth.
Each day of the workshop, will consist of 3 primary speakers (1-hour lectures each) that will include an experimentalist laying out the biological problem, a mathematical modeler describing modeling approaches and a imaging specialist describing the type of data (typically imaging) available for model validation and development. Additionally, other attendees will be invited to present posters at the poster session. An expert panel will comprise of leading modelers and experimentalists to discuss current problems in the efficient translation of mathematical modeling techniques to the laboratory and the clinic.
Significant time will be available during the meeting for discussions of current and future problems in the cancer and tumor-induced angiogenesis area.
Accepted Speakers
- Alexander (Sandy) Anderson (Co-Director of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute)
- Gustavo Ayala (Departments of Pathology, Urology, and Molecular and Cellular Biology, Baylor College of Medicine)
- Carlo Croce (College of Medicine, The Ohio State University)
- Daniel Gallahan (Division of Cancer Biology, National Cancer Institute)
- Robert Gatenby (H. Lee Moffitt Cancer Center & Research Institute)
- Robert Gillies (Department of Radiology and Director, ARIBI, Arizona Cancer Center)
- Trachette Jackson (Department of Mathematics, University of Michigan)
- John Lowengrub (Department of Mathematics, University of California, Irvine)
- Lance Munn (Massachusetts General Hospital & Harvard Medical School)
- Carl Panetta (Department of Phamaceutical Sciences, St. Jude Children's Research Hospital)
- Aleksander Popel (Department of Biomedical Engineering, School of Medicine, Johns Hopkins University)
- Vito Quaranta (Vanderbilt Ingram Cancer Biology Center, Vanderbilt University)
- Jason Rockhill (Department of Radiation Oncology and Neurological Surgery, University of Washington)
- Kristin Swanson (Department of Pathology, University of Washington)
- Forest White (Department of Biological Engineering, Massachusetts Institute of Technology)
- Muhammad Zaman (Department of Biomedical Engineering and Institute of Theoretical Chemistry, The University of Texas at Austin)
Accepted Participants
- David Basanta (Lee Moffitt Cancer Center and Research Institute)
- Gargi Chakraborty (Department of Pathology, University of Washington Medical Center)
- Ennio Antonio Chiocca (Department of Neurological Sugery, The Ohio State University)
- Lisette de Pillis (Department of Mathematics, Harvey Mudd College)
- Heiko Enderling (Center of Cancer Systems Biology, Caritas St. Elizabeth's Medical Center)
- Renee Fister (Department of Mathematics and Statistics)
- James Glazier (Department of Physics, Indiana University)
- Bo Guan (Department of Mathematics, The Ohio State University)
- Simon Hayward (Vanderbilt University Medical Center)
- Marek Kimmel (Department of Statistics, Rice University)
- Misha Kutzman
- Urszula Ledzewicz (Department of Mathematics and Statistics, Southern Illinois University Edwardsville)
- Georg Luebeck (Program in Computational Biology, Fred Hutchinson Cancer Research Center)
- Ralf Lukner (Baylor College of Medicine)
- Susan Massey (Department of Pathology, University of Washington)
- Michael Milosevic (Radiation Medicine Program, Princess Margaret Hospital and University Health Network)
- Kasia Rejniak (Integrated Mathematical Oncology, Moffitt Cancer Center & Research Institute)
- Russ Rockne (Department of Pathology, University of Washington)
- Heinz Schaettler (Department of Electrical and Systems Engineering, Washington University, Saint Louis)
- Christina Wang (University of Washington)
- Tongli Zhang (Department of Biology, Virginia Tech)
